We have sequenced and analyzed the genome of the previously unculturable clinical strain Paenibacillus sp. strain VT-400, an aerobic, rod-shaped, motile (via peritrichous flagella), endospore-forming, gram-positive bacterium that was isolated from the saliva of a child with acute lymphoblastic leukemia.
Paenibacillus sp. strain VT-400 is aerobic, rod-shaped, motile (via peritrichous flagella), endospore-forming Gram-positive bacteria.
Fig.1 TEM micrographs of Paenibacillus sp. strain VT-400
Paenibacillus sp. strain VT-400 is a representative of family Paenibacillaceae, which has recently been shown to contain several medically important species associated with urinary tract infections, pneumonia, and bacteremia in humans. The genome of strain VT-400 contains numerous multidrug resistance transporters, including SMR efflux pumps that confer resistance to nosocomial antibiotics, genes encoding resistance to chemotherapeutic drugs used in the treatment of hematological malignancies, etc. The organism also harbors a large number of genes encoding virulence factors such as hemolysin D and CD4+ T cell-stimulating antigen.
Paenibacillus sp. strain VT-400 spores are highly resistant to heat, antibiotics, and chemicals.
Nucleotide sequence accession number
This genome sequencing project has been deposited in GenBank under the accession No. LELF00000000.
The Paenibacillus sp. strain VT-400 strain is deposited
DSMZ under accession number: DSM 100755.
ATCC under accession number: BAA-2757
IDAC under accession number: 021115-2