Longevity and Aging Research Program

«The human lifespan (T-life) exists within limited boundaries. What if we could push those boundaries?» G.Tetz

The major research of Human Microbiology Institute is focused on longevity and aging. Increasing the human lifespan is the most commonly accepted goal of medicine resulting in the postponement of death, preserving life and support maintenance of vital functions and productive lifespan as long as possible. It is shown that individual longevity is attributed to the particularities of host microbiota. HMI’s longevity and aging research program strategy is to  manage aging as the disease and to find ways to postpone its onset. Based on our knowledge we have made amazing advances in our understanding of the mechanisms behind microbiota envolvement in lifespans and that it is a new inflection point in human longevity and age-related processes.

With the goal of developing principally new therapeutic options, the HMI has successfully applied  a state-of-the-art  breakthrough theoretical basis to identify new targets to increase a lifespan.

  • Tetz Theory of longevity
  • Microbiota diseases
  • The Pangenome concept
  • Maternal inheritance of microbiota

Designed theories open up new directions in biology, similar to chemical periodic law.  That is, allow  for the identification of new connections and patterns, and the next indicates new targets affecting which can make possible to increase individual lifespan.

We developed Tetz’s theory of  longevity that has an explanatory and predictive potential for longevity and aging and can be used to evaluate new fundamental aspects that control these processes.  Overall Tetz’s theory of  longevity is based on the longevity of macroorganism using the supra-organismal approach and observation of the interdependent and inseparable role of microbiota in human lifespan.

tsupt = tlife

A further use of the theory and Tetz’s law, as a tool in studying longevity, should help to re-examine the aging process, the causes of mortality and to provide insights that may help to reduce rate of aging and extend the lifespan.

Based on HMI research, novel anti-aging products and therapeutic strategies intended to increase lifespan will be developed.


Novel Microbial Search that Affect Longevity

The HMI is working to elucidate the particularities of host-microbiota cross-talk, and identify microorganisms that might trigger the onset and progression of aging.

Using unique methods developed by HMI scientists will further our understanding of the role of microbiota in longevity and will thereby may ultimately give rise to a system for personalized microbiota care to slow down the aging process.


HMI is delighted to present an innovative computational platform technology “T-life” of modulating human longevity that now is being developed by our core. Using computer science HMI will  dramatically increase longevity and postpone ageing, already within the next decade.  T-life is based on the unique groundbreaking mathematical model described in  “Tetz’s theory and law of longevity” that for the first time takes into consideration  previously unexplored fundamental aspects of longevity and causes of aging.

T-Life Highlights

  • Expanding the frontiers of human longevity
  • Will extend the healthy life expectancy
  • Based on previously unexplored causes of aging
  • Determined by the unique algorithm of the influence  of the accumulation of alterations in the totality of genes of macroorganism and microbiome and the non-living genetic elements on human longevity
  • Pioneering at the intersection of medicine,  biology and computer science disciplines

The HMI is currently developing a unique product that is based on unanticipated results obtained from a study of distinct mechanisms of cooperation between the microbiota and mitochondria, named “HMI-M-Transplantat”. This therapeutic solution for the first time takes into consideration the unexpected link between the microbiota and the host organism, and is based on Tetz’s Theory of longevity, theory of maternal inheritance of microbiota, diseases of the microbiota, and the Pangenome concept. Moreover, the HMI is developing individualized algorithms for the usage of this unique product to increase human longevity  and slow down the aging process.


Our research, based on theories developed here at the HMI, has revealed entirely new aspects of the biology of longevity, and has identified a new group of potential therapeutic targets to increase human lifespan. By targeting these factors, it may be possible to slow down the aging process. Moreover, our findings have resulted in the development of a first-in-class, potentially groundbreaking, therapeutic solution named NT-49, which is currently under intensive study at the HMI.

The Human Microbiology Institute is dedicated to collaborate with other research organizations and entities involved in this field. To that end the HMI will develop means by which to make the results of this research widely available on a non- discriminatory basis.

Tetz’s theory and law of longevity.

Theory in Biosciences (2018)

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Publication Type Article
Authors G.Tetz

V. Tetz

Abstract Here, we present new theory and law of longevity intended to evaluate fundamental factors that control lifespan. This theory is based on the fact that genes affecting host organism longevity are represented by subpopulations: genes of host eukaryotic cells, commensal microbiota, and non-living genetic elements. Based on Tetz’s theory of longevity, we propose that lifespan and aging are defined by the accumulation of alterations over all genes of macroorganism and microbiome and the non-living genetic elements associated with them. Tetz’s law of longevity states that longevity is limited by the accumulation of alterations to the limiting value that is not compatible with life. Based on theory and law, we also propose a novel model to calculate several parameters, including the rate of aging and the remaining lifespan of individuals. We suggest that this theory and model have explanatory and predictive potential to eukaryotic organisms, allowing the influence of diseases, medication, and medical procedures to be re-examined in relation to longevity. Such estimates also provide a framework to evaluate new fundamental aspects that control aging and lifespan.
Year of Publication 2018
Journal Theory in Biosciences
DOI https://doi.org/10.1007/s12064-018-0267-4