The Universal Receptive System is a newly described by our scientific core cellular regulatory system that helps explain how cells sense, respond to, and adapt to their environment.
This system is composed of DNA- and RNA-based Teazeled receptors (TezRs) found on the surface of prokaryotic and eukaryotic cells, as well as integrases and recombinases. TezRs receptors are present in both bacterial, plant, fungi, and human cells and appear to play a central role in regulating cellular behavior.
Unlike traditional receptor systems, the Universal Receptive System is not limited to one pathway or one type of signal. Instead, it functions as a broad regulatory network that influences how cells respond to stress, infection, immune signals, antibiotics, and other environmental conditions.
In microorganisms, this system affects clinically important behaviors such as biofilm formation, antibiotic tolerance, resistance patterns, and adaptation to hostile environments. This helps explain why bacteria in real infections often behave differently from bacteria tested in isolation under standard laboratory conditions.
In human immune cells, modulation of the Universal Receptive System can change cellular activity and enhance immune function. This forms the biological foundation for the development of Leukocyte-Tells and the SL-28 cell therapy platform.
Through this approach, immune cells can be functionally reprogrammed outside the body without genetic engineering. The goal is to enhance their natural antimicrobial and anticancer activity and then return them to the patient as a therapeutic cellular product.
The discovery of the Universal Receptive System opens a new direction in cell biology, infectious disease, immunology, and regenerative medicine. It provides a novel way to understand cellular memory, adaptation, and therapeutic reprogramming.
References
- Tetz V, Tetz G. “Novel prokaryotic system employing previously unknown nucleic acids-based receptors.” Microbial Cell Factories. 2022;21:1–33. DOI: 10.1186/s12934-022-01923-0.
- Tetz V, Tetz G. “Novel Cell Receptor System of Eukaryotes Formed by Previously Unknown Nucleic Acid-Based Receptors.” DNA. 2022.
- Tetz G, Kardava K, Vecherkovskaya M, Khodadadi-Jamayran A, Tsirigos A, Tetz V. “Universal receptive system as a novel regulator of transcriptomic activity of Staphylococcus aureus.” Microbial Cell Factories. 2025;24:1. DOI: 10.1186/s12934-024-02637-1.
- Tetz V, Kardava K, Vecherkovskaya M, Khodadadi-Jamayran A, Tsirigos A, Tetz G. “Previously unknown regulatory role of extracellular RNA on bacterial directional migration.” bioRxiv / PubMed preprint record. 2024.
- Tetz V, Kardava K, Vecherkovskaya M, Khodadadi-Jamayran A, Tsirigos A, Tetz G. “Regulating white blood cell activity through the novel universal receptive system.” Scientific Reports. 2025.
- Tetz V, Kardava K, Vecherkovskaya M, Khodadadi-Jamayran A, Tsirigos A, Tetz G. “The Universal Receptive System acts as a novel regulator in the production of antimicrobial and anticancer bioactive compounds by white blood cells.” Journal of Leukocyte Biology. 2025.
- Tetz V, Kardava K, Vecherkovskaya M, Khodadadi-Jamayran A, Tsirigos A, Tetz G. “Dramatic Clinical Response to a Novel Form of Cell Therapy SL-28 in a Patient With Advanced Prostate Cancer: A Case Report.” ImmunoTargets and Therapy. 2025.
- “Partial response in a patient with skeletal and hepatic metastases following resected pancreatic cancer to the novel cell therapy SL-28: a case report.” Frontiers in Oncology. 2025.