The Human Microbiology Institute is delighted to introduce novel group of human diseases:“Microbiota Diseases”. The term “microbiota diseases” reflects the primary and crucial role of microbiota-related disorders in certain host organism pathologies.
HMI research indicates that microbiota diseases lead to pathologies in the macroorganism, including increased intestinal permeability and leaky gut-associated pathologies, including:
- Inflammatory bowel disease
- Crohn’s disease
- Alzheimer’s disease
- Amyotrophic lateral diseases
- Parkinson’s disease
- Schizophrenia
- Autism
- Type 1 diabetes
- Cancers
- Cardiovascular disorders
- Rheumatoid arthiritis
- Liver and kidney failure
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We try to make our data available to the whole scientific community. The HMI welcomes collaborative studies to unravel the pathogenesis of human diseases associated with the microbiota. However, we ask that you respect the rights of first publication and cite our work as follows:
Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model.
Gut pathogens (2016)
Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model.
| Publication Type |
Journal Article |
| Authors |
George Tetz
Victor Tetz |
| Abstract |
Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. The role of microbiota in increased intestinal permeability is under intensive investigation. Here, we studied alterations in the host and increased intestinal permeability as a direct effect of treatment with a bacteriophage cocktail. After 10 days of challenge, the rats showed weight loss, messy hair, and decreased activity. Additionally, they displayed a significantly elevated lactulose:mannitol ratio and the level of circulating immune complexes. To our knowledge, this study demonstrates for the first time that increased intestinal permeability may be induced by bacteriophages that affect the microbiota. |
| Year of Publication |
2016 |
| Journal |
Gut pathogens |
| DOI |
10.1186/s13099-016-0109-1 |