Sporobiota and Sporobiome

We identified unique common characteristics of spore-forming bacteria that have serious implications for human health allowing us to identify these bacteria as an independent element named “Sporobiota”

  1. Members of sporobiota form spores that are highly resistant to numerous environmental challenges and are insensitive to antibiotic exposure and the host immune defense system.
  2. Due to this infections caused by sporeforming bacteria share similar characteristics, such as persistence, chronicity and relapses.
  3. Members of Sporobiota are highly transmissible, and disseminate through host-to-host (including patient-to-patient) transmission, and from the outer environment (including medical surroundings) to humans.
  4. Members of Sporobiota harbor multiple antibiotic resistance genes that are localized within the specific elements responsible for transferring and thus facilitating the spread of antibiotic resistance.
  • SPOROBIOTA – Specifically influenced by natural selection
  • SPOROBIOTA – Have an individual arrangement for fitness costs of antibiotic resistance
  • SPOROBIOTA – Resistant to various physico-chemical treatments, including antibiotics
  • SPOROBIOTA – Have strong binding properties
  • SPOROBIOTA – Highly transmissible
  • SPOROBIOTA – Implicated in the spread of antibiotic resistance
  • SPOROBIOTA – Infections caused by sporeforming bacteria share similar characteristics: persistence, chronicity, relapses

We try to make our data available to the whole scientific community. The HMI welcomes collaborative studies to unravel the pathogenesis of human diseases associated with the microbiota. However, we ask that you respect the rights of first publication and cite our work as follows:

Introducing the sporobiota and sporobiome.

Gutpathogens. 2017 Dec;9(1):38.

Publication Type Journal Article
Authors George Tetz

Victor Tetz

Abstract Unrelated spore-forming bacteria share unique characteristics stemming from the presence of highly resistant endospores, leading to similar challenges in health and disease. These characteristics are related to the presence of these highly transmissible spores, which are commonly spread within the environment and are implicated in host-to-host transmission. In humans, spore-forming bacteria contribute to a variety of pathological processes that share similar characteristics, including persistence, chronicity, relapses and the maintenance of the resistome. We first outline the necessity of characterizing the totality of the spore-forming bacteria as the sporobiota based on their unique common characteristics. We further propose that the collection of all genes of spore-forming bacteria be known as the sporobiome. Such differentiation is critical for exploring the cross-talk between the sporobiota and other members of the gut microbiota, and will allow for a better understanding of the implications of the sporobiota and sporobiome in a variety of pathologies and the spread of antibiotic resistance.
Year of Publication 2017
Journal Gut pathogens
DOI 10.1186/s13099-017-0187-8