Key antibiotic resistance genes in the Kluyvera intestini GT-16
Number of genes | Function |
5 | Multidrug ABC transporter permease |
4 | MFS transporter |
1 | MATE family efflux transporter |
1 | Multidrug efflux RND transporter permease subunit |
1 | Tellurium resistance protein TerA |
1 | Tellurium resistance protein TerZ |
1 | Tellurium resistance protein TerB |
1 | Tellurium resistance protein TerC |
1 | Tellurium resistance protein TerF |
1 | Tellurium resistance protein TerW |
1 | Chemical-damaging agent resistance protein C |
1 | Arsenical resistance protein ArsH |
1 | Multiple antibiotic resistance regulatory periplasmic protein MarB |
1 | EmrB/QacA family drug resistance transporter |
1 | Bleomycin resistance protein |
1 | Copper resistance protein CopD |
1 | Colicin M resistance protein CbrA |
1 | Beta-lactam resistance protein |
1 | Class A beta-lactamase |
1 | Chloramphenical resistance permease RarD |
1 | QacE family quaternary ammonium compound efflux SMR transporter |
1 | MDR efflux pump AcrAB |
1 | Macrolide transporter subunit MacA |
1 | Macrolide ABC transporter permease/ATP-binding protein MacB |
Genomic analysis revealed that Kluyvera intestini GT-16 harbors numerous antibiotic resistance genes that catalyze uptake, efflux, diffusion, solute exchange, and other mechanisms of bacterial defense against antibiotics.