Spread of Antibiotic Resistance

Key antibiotic resistance genes in the Kluyvera intestini GT-16

Number of genes Function
5 Multidrug ABC transporter permease
4 MFS transporter
1 MATE family efflux transporter
1 Multidrug efflux RND transporter permease subunit
1 Tellurium resistance protein TerA
1 Tellurium resistance protein TerZ
1 Tellurium resistance protein TerB
1 Tellurium resistance protein TerC
1 Tellurium resistance protein TerF
1 Tellurium resistance protein TerW
1 Chemical-damaging agent resistance protein C
1 Arsenical resistance protein ArsH
1 Multiple antibiotic resistance regulatory periplasmic protein MarB
1 EmrB/QacA family drug resistance transporter
1 Bleomycin resistance protein
1 Copper resistance protein CopD
1 Colicin M resistance protein CbrA
1 Beta-lactam resistance protein
1 Class A beta-lactamase
1 Chloramphenical resistance permease RarD
1 QacE family quaternary ammonium compound efflux SMR transporter
1 MDR efflux pump AcrAB
1 Macrolide transporter subunit MacA
1 Macrolide ABC transporter permease/ATP-binding protein MacB

Genomic analysis revealed that Kluyvera intestini GT-16 harbors numerous antibiotic resistance genes that catalyze uptake, efflux, diffusion, solute exchange, and other mechanisms of bacterial defense against antibiotics.