Biology of Blood and Marrow Transplant (2015)
| Publication Type | Journal Article |
| Authors | Dan Li Rebecca Patenia Roland Bassett Jr. George Tetz Richard E. Champlin Qing Ma |
| Abstract | Graft-versus- host-disease (GVHD) is an alloimmune response complicating allogeneic hematopoietic stem cell transplantation (allo-HSCT). The development of GVHD is thought to involve three phases: T cell activation, followed by proliferation and differentiation of allogeneic T cells into activated effector cells, and finally specific tissue damage. In the activation phase, donor T cells interact with host APCs, leading to activation and differentiation toward the effector pathway and migration of these cells to target tissues affected during acute GVHD. |
| Year of Publication | 2015 |
| Journal | Biology of Blood and Marrow Transplant |
| DOI | 10.1016/j.bbmt.2014.11.540 |